ABSTRACT
The effects of human fetal hepatic stimulator substance (h-HSS) and liver cytosol (h-FLC) on the survival rate,the intensity of liver damage,and liver regeneration in rats with liver necrosis induced with D-galactosamine were observed.The physico-chemical properties of h-HSS were preliminarily determined.It was found that both h-HSS and H-FLC could markedly increase the.survival rate of the rats with toxic liver necrosis,significantly decrease the serum level of ornithine carbamoyl transferase and mitochondria aspartic trans-aminase,improve the hepaplastin activity,and elevate the incorporation rate of 3H-thymidine with liver DNA.h-HSS was stable after heated to 95℃ for 30 minutes,and sensitive to trypsin treatment.It demonstrated one major band at 15 000 daltons and 3 minor ones at 24 000,34 000,and 40 000 daltons respectively on sodium dodecyl sulfate-polyacrylamide gel electrophoresis.The relative content of the major band was 47.57%.
ABSTRACT
Thirty-four patients with severe chronic active viral hepatitis were divided into 2 groups. One group was treated with prostaglandin E_1, (PGE_1,) and supportive therapy, and the other was treated with supportive therapy only and served as the control. The effects of PGE_1, on plasma lipid peroxides (LPO) level, plasma prostacyclin (PGI_2) and thromboxane A_2 (TXA_2), plasma cyclic nucleotide and liver function were determined to investigate the mechanism of PGE1. It was found that PGE_1 could achieve the following effects.1. Reduction of plasma LPO level (P
ABSTRACT
This paper is to report the results of comprehensive treatment for 78 patients with severe viral hepatitis(SVH). The overall survival rate was 39.74%, and the survival rates of subacute and chronic SVH were 48.39% and 34.04% respectively. Compared with the survival rate of 10-30% reported abroad and 27.9% of our previous report, the survival rate after comprehensive therapy was slightly improved.After analyzing the results, the authors suggest that besides early diagnosis, prompt treatment, intensive basic treatment, and energetic prevention ' and treatment of the complications, further exploration for new and effective therapeutic agents be of prime importance to improve the survival rate of SVH.
ABSTRACT
This paper is to report the study of the microscopic and macroscopic he-morrheological changes and the conditions of the nail-fold microcirculation in 30 patients with severe viral hepatitis. Normal 'individuals, patients with acute icteric hepatitis, and those with chronic active hepatitis were employed as the controls.The changes observed in the patients with severe viral hepatitis were as follows: The reduced viscosity of the whole blood and the plasma viscosity increased markedly, the dispersion rate of the blood viscosity values increased as the clinical state of the patient became more severe, and the factors increasing the blood viscosity (namely, increase of the amount of immune globulin, pro-longation of the electrophoretic time of RBC, increase of RBC sedimentation rate), and the factors decreasing the blood viscosity (namely, decreases of he-matocrit reading, fibrinogen, and the aggregation ratio of platelets) existed simultaneously. The changes of the flow condition and velocity of the nail-fold microcirculation were in close correlation with the increase of blood viscosity and the severity of the disease.The causes and the mechanism of the above-mentioned changes were discussed.